Cyanosis is the change of body tissue color to a bluish-purple hue as a result of having decreased amounts of oxygen bound to the hemoglobin in the red blood cells of the capillary bed.[1] Body tissues that show cyanosis are usually in locations where the skin is thinner, including the mucous membranes, lips, nail beds, and ear lobes.[1] Some medications containing amiodarone or silver, Mongolian spots, large birth marks, and the consumption of food products with blue or purple dyes can also result in the bluish skin tissue discoloration and may be mistaken for cyanosis.[2][3] Show
Cyanosis is further classified into central cyanosis vs. peripheral cyanosis. Pathophysiology[edit]The mechanism behind cyanosis is different depending on whether it is central or peripheral. Central cyanosis[edit]Central cyanosis is caused by a decrease in arterial oxygen saturation (SaO2) and begins to show once the concentration of deoxyhemoglobin in the blood reaches a concentration of ≥ 5.0 g/dL (≥ 3.1 mmol/L or oxygen saturation of ≤ 85 %).[4] Causes of central cyanosis are discussed below. Peripheral cyanosis[edit]Peripheral cyanosis happens when there is increased concentration of deoxyhemoglobin on the venous side of the peripheral circulation. In other words, cyanosis is dependent on the concentration of deoxyhemoglobin. Patients with severe anemia may appear normal despite higher than normal concentrations of deoxyhemoglobin. On the other hand, patients with increased amounts of red blood cells (e.g. polycythemia vera) can appear cyanotic even with lower concentrations of deoxyhemoglobin.[5][6] A baby with a heart condition. Note purple nailbeds. Central cyanosis[edit]Central cyanosis is often due to a circulatory or ventilatory problem that leads to poor blood oxygenation in the lungs. It develops when arterial oxygen saturation drops below 85% or 75%.[5] Acute cyanosis can be a result of asphyxiation or choking and is one of the definite signs that ventilation is being blocked. Child with congenital heart disease with central cyanosis that is worsened by measles. Note the bluish-purple discoloration of the fingernails, lips, eyelids, and nose, along with prominent nail clubbing. Central cyanosis may be due to the following causes:
Peripheral cyanosis[edit]Peripheral cyanosis is the blue tint in fingers or extremities, due to an inadequate or obstructed circulation.[5] The blood reaching the extremities is not oxygen-rich and when viewed through the skin a combination of factors can lead to the appearance of a blue color. All factors contributing to central cyanosis can also cause peripheral symptoms to appear but peripheral cyanosis can be observed in the absence of heart or lung failures.[5] Small blood vessels may be restricted and can be treated by increasing the normal oxygenation level of the blood.[5] Initial direction of blood flow in patients with patent ductus arteriosus. Once the pressure of the pulmonary arteries increases more than the aorta due to right heart hypertrophy, the direction of blood flow reverses, sending deoxygenated blood through the patent duct directly into the descending aorta while sparing the brachiocephalic trunk, left common carotid, and left subclavian artery, therefore causing the differential cyanosis. Peripheral cyanosis may be due to the following causes:[5] Differential cyanosis[edit]This illustration depicts a self-induced local (tissue) hypoxia on the right hand (right side of the picture) versus a normal left hand (left side of the picture). The cyanosis was achieved by inflating and tightening the blood pressure cuff on the right arm. Differential cyanosis is the bluish coloration of the lower but not the upper extremity and the head.[5] This is seen in patients with a patent ductus arteriosus.[5] Patients with a large ductus develop progressive pulmonary vascular disease, and pressure overload of the right ventricle occurs.[8] As soon as pulmonary pressure exceeds aortic pressure, shunt reversal (right-to-left shunt) occurs.[8] The upper extremity remains pink because deoxygenated blood flows through the patent duct and directly into the descending aorta while sparing the brachiocephalic trunk, left common carotid, and left subclavian arteries. Evaluation[edit]A detailed history and physical examination (particularly focusing on the cardiopulmonary system) can guide further management and help determine the choice of testing to be performed.[1] Tests that can be performed include pulse oximetry, arterial blood gas, complete blood count, methemoglobin level, electrocardiogram, echocardiogram, X-Ray, CT scan, cardiac catheterization, and hemoglobin electrophoresis. In newborns, peripheral cyanosis typically presents in the distal extremities, circumoral, and periorbital areas.[9] Of note, mucous membranes remain pink in peripheral cyanosis as compared to central cyanosis where the mucous membranes are cyanotic.[9] This picture shows cyanosis in an individual with darker skin pigmentation. Note the pale purple (instead of the typical bluish-purple hue) nail beds. This patient also had prominent digital clubbing due to a congenital heart disease with right-to-left shunting (this patient had Tetralogy of Fallot). It is important to note that skin pigmentation and hemoglobin concentration can affect the evaluation of cyanosis. Cyanosis may be more difficult to detect on people with darker skin pigmentation. However, cyanosis can still be diagnosed with careful examination of the typical body areas such as nail beds, tongue, and mucous membranes where the skin is thinner and more vascular.[1] As mentioned above, patients with severe anemia may appear normal despite higher than normal concentrations of deoxyhemoglobin.[5][6] Signs of severe anemia may include pale mucosa (lips, eyelids, and gums), fatigue, lightheadedness, and irregular heartbeats. Another example of cyanosis in an elderly individual with darker skin pigmentation. Note the dark purple hue of the lips. Management[edit]Cyanosis is a symptom rather than a disease itself, so management should be focused on treating the underlying cause. If it is an emergency, management should always begin with securing the airway, breathing, and circulation. In patients with significant respiratory distress, supplemental oxygen (in the form of nasal canula or continuous positive airway pressure depending on severity) should be given immediately.[10][11] If the methemoglobin levels are positive for methemoglobinemia, first-line treatment is to administer methylene blue.[1] History[edit]The name cyanosis literally means the blue disease or the blue condition. It is derived from the color cyan, which comes from cyanós (κυανός), the Greek word for blue.[12] It is postulated by Dr. Christen Lundsgaard that cyanosis was first described in 1749 by Jean-Baptiste de Sénac, a French physician who served King Louis XV.[13] De Sénac concluded from an autopsy that cyanosis was caused by a heart defect that led to the mixture of arterial and venous blood circulation. But it was not until 1919, when Dr. Lundsgaard was able to derive the concentration of deoxyhemoglobin (8 volumes per cent) that could cause cyanosis.[13] What is a bluish discoloration of the skin and mucous membranes called?Cyan means 'blue' and the abnormal bluish discoloration of the skin and mucous membranes is referred to as “cyanosis”. It is a pathologic sign, and not a disease by itself. Underlying diseases that increase the deoxygenated hemoglobin to 5.0 g/dl or more leads to cyanosis.
What is a discoloration of the skin and mucous membranes caused by the oxygenation of the blood?8 What is cyanosis? Cyanosis is bluish discoloration of the skin, mucosa or both due to reduced oxygenation of the blood. Clinically, it becomes evident when the oxygenation of hemoglobin falls below 85%.
What is the medical term for bluish tinge to the skin and mucous membranes due to below normal oxygen levels?Cyanosis is caused by an increase in the deoxygenated hemoglobin level to above 5 g/dL. Patients who have anemia do not develop cyanosis until the oxygen saturation (also called SaO2) falls below normal hemoglobin levels.
What is cyanosis caused by?Cyanosis is usually caused by problems of the heart, lungs, or blood. Some of the heart conditions that can cause a child to have cyanosis are: truncus arteriosus. total anomalous pulmonary venous return.
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