The mechanism of nuclear membrane reassembly is debated. In cells where nuclear membranes fragments into vesicles during mitosis, a Ran-GTP–dependent pathway directs at least two discrete populations of vesicles to chromatin where they fuse to reform the nuclear envelope. In cells where the nuclear membrane is absorbed into the endoplasmic reticulum during mitosis, reassembly involves lateral movements of membrane components within the membrane network and their stabilization at preferred binding sites at the periphery of the chromosomes. If you believe that content available by means of the Website (as defined in our Terms of Service) infringes one or more of your copyrights, please notify us by providing a written notice (“Infringement Notice”) containing the information described below to the designated agent listed below. If Varsity Tutors takes action in response to an Infringement Notice, it will make a good faith attempt to contact the party that made such content available by means of the most recent email address, if any, provided by such party to Varsity Tutors. Your Infringement Notice may be forwarded to the party that made the content available or to third parties such as ChillingEffects.org. Please be advised that you will be liable for damages (including costs and attorneys’ fees) if you materially misrepresent that a product or activity is infringing your copyrights. Thus, if you are not sure content located on or linked-to by the Website infringes your copyright, you should consider first contacting an attorney. Please follow these steps to file a notice: You must include the following: A physical or electronic signature of the copyright owner or a person authorized to act on their behalf; An identification of the copyright claimed to have been infringed; A description of the nature and exact location of the content that you claim to infringe your copyright, in \ sufficient detail to permit Varsity Tutors to find and positively identify that content; for example we require a link to the specific question (not just the name of the question) that contains the content and a description of which specific portion of the question – an image, a link, the text, etc – your complaint refers to; Your name, address, telephone number and email address; and A statement by you: (a) that you believe in good faith that the use of the content that you claim to infringe your copyright is not authorized by law, or by the copyright owner or such owner’s agent; (b) that all of the information contained in your Infringement Notice is accurate, and (c) under penalty of perjury, that you are either the copyright owner or a person authorized to act on their behalf. At the beginning of the first mitotic stage, prophase, the thread-like doubled chromosomes contract and become visible. The two centrioles move to opposite sides of the nucleus. At the same time, the nuclear membrane begins to break down. 
During metaphase, the nuclear membrane disappears and the chromosomes become aligned half way between the centrioles. The centromere of each doubled chromosome becomes attached by thread-like spindle fibers to the centrioles which are at polar opposite sides of the cell.
During the following anaphase stage, the chromatids of each chromosome separate at their centromeres and then migrate to the opposite poles of the cell.
During telophase, two distinct nuclear membranes develop encompassing the two identical sets of chromosomes. At the same time, the cytoplasm divides between the two new cells, and the cell membrane begins to pinch off the cell contents into two daughter cells.
Finally, the new identical cells separate and once again enter interphase in preparation for a later mitotic division. While the chromosomes are no longer visible, they will be replicated just before mitosis begins. If you're seeing this message, it means we're having trouble loading external resources on our website. If you're behind a web filter, please make sure that the domains *.kastatic.org and *.kasandbox.org are unblocked. |
